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Collectively, these data show that DMF constitutes an attractive compound for the pharmaceutical industry for drug repurposing in other neurodegenerative diseases ( TABLE 1 DMFs ability to alleviate pathological hallmarks of AD, PD and ALS in pre-clinical models in the context of Nrf2 activation

In cell cultures, it prevents the cytotoxic effects of both externally added tau fibrils and internally expressed tau mutants [124]

The 30 standard redox potentials of the thiol-disulfide couples are determined for the first time

Regulation is achieved also by post-translational modifications (PTMs) as phosphorylation or myristoylation and by allosteric effectors like NADPH [20]